I need to add my user to group “dialout” to access the serial port (ttyUSB0), $ sudo adduser audhil dialout Yes my development board is connected with development system at /dev/ttyUSB0. usb 7-1: FTDI USB Serial Device converter now attached to ttyUSB0 So, I decided to remove it $ sudo apt-get remove brltty After googling I found the reason behind this is brltty (used for blinds) refer this. When I tried to plug my development board, I saw serial port as ttyUSB0, but unfortunately it disappeared / disconnected.